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See 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) Circulation bloodborne versus series, 61 acutance of, 61 impersonation in unpredictable knock out retort, 62 volume of distribution, 63 DNA adducts effects on enlarge helix stability, 233 generation at near 4-aminobiphenyl, 308 generation by aristolochic acid, 250 appearance beside epoxy 1,3-butadiene, 310 formation close to genotoxic carcinogens, 232 materialization alongside PAH in smokers, 301 generation by vinyl chloride, 248 accumulation during spirits exposure, 267 institution from acrolein in smokers, 297 composition via endogenous pathways, 240 multiplicity of routes to guanine adduction in smokers, 310 pyridyloxobutyl DNA adducts in smokers, 305 quantitation past postlabelling, 240 doing away with via NER, 238 improvement mechanisms, 236 r“le in apoptosis induction, 238 reflect on via site-sepecific mutagenesis, 235 mixture of adducted oligodeoxynucleotides, 232 DNA glycosylases, task in position excision repair, 238 DNA polymerases, lines in evolving induction, 234 DNA patch adduct reversal (e. 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